How Does Mytesi Work?

How Does Mytesi Work?

What you may expect ​from taking Mytesi

HIV-related diarrhea results from an imbalance of salts and water in the gastrointestinal (GI) tract, or gut. Mytesi works by restoring the balance of salts and water in the gut, normalizing the flow of water and resulting in less watery diarrhea.1

  • Normal

    Chloride ion (Cl–) channels in the gastrointestinal (GI) tract maintain a balance of salts—including chloride ions—and water that allows normal stool formation.

  • Diarrhea

    Ion channels that don’t work properly lead to too much salt and water within the gut, disrupting the normal balance and resulting in diarrhea.

  • Starting Mytesi

    Mytesi restores the balance of salts and water in the GI tract by normalizing improperly functioning chloride ion (Cl–) channels.

  • Long-term Results

    After 3-4 weeks, Mytesi can reduce the severity of watery bowel movements and provide sustained long-term relief.1 In nonclinical studies, crofelemer, the active ingredient in Mytesi, does not slow down gut motility and is therefore less likely to cause constipation.

Mytesi works differently than other treatments for diarrhea. With Mytesi, it’s about water flow.

Mytesi works to normalize the amount of water in your gut. Less water flowing into your gut = Less watery diarrhea.

Mytesi acts directly on the GI tract—it is minimally absorbed into the bloodstream, which means it doesn’t travel through your whole body.

In clinical studies, Mytesi did not interact with antiretroviral therapy. Mytesi also did not affect viral load or CD4 counts.

Mytesi offers advantages

In clinical studies, Mytesi did not show any clinically meaningful interactions with other medicines, meaning it is unlikely to affect how well your antiretroviral therapy (ART) works.

In clinical studies, Mytesi did not affect HIV viral load or CD4 counts.

Help address the diarrhea-constipation cycle

Help address the diarrhea-constipation cycle

Over 98% of people taking Mytesi in clinical studies did not report any constipation.1

Most other diarrhea medicines work by slowing down your gut, which may stop diarrhea in the short term, but can cause constipation.
Mytesi reduces watery diarrhea by restoring water balance in the gut with a low risk of constipation.
Mytesi may help address the diarrhea-constipation cycle that can happen with other diarrhea medicines.1

Taking Mytesi continuously may further help prevent symptoms from returning. Do not stop taking Mytesi unless directed by your healthcare provider.

Mytesi provides symptomatic relief of
noninfectious HIV-related diarrhea.

Mytesi provides symptomatic relief of noninfectious HIV-related diarrhea.

Reference: 1. Mytesi [package insert]. San Francisco, CA: Napo Pharmaceuticals Inc; 2018.